By John N. Abelson, Melvin I. Simon, Alfred H. Merrill Jr., Yusuf A. Hannun
Sphingolipids are present in all eukaryotic and in a few prokaryotic organisms and supply constitution for phone membranes, lipoproteins, and different organic fabrics in addition to perform the rules of phone development, differentiation, and various phone services, together with cell-cell verbal exchange, cell-substratum interactions, and intracellular sign transduction. This quantity provides tools utilized in learning enzymes of sphingolipid biosynthesis and turnover, together with inhibitors of a few of those enzymes, genetic methods, and natural and enzymatic syntheses of sphingolipids and analogs. Its significant other Volume 312 will include info on examining sphingolipids, sphingolipid delivery and trafficking, and sphingolipid-protein interactions and mobile targets.
The seriously acclaimed laboratory ordinary for greater than 40 years, Methods in Enzymology is likely one of the so much hugely revered guides within the box of biochemistry. for the reason that 1955, every one quantity has been eagerly awaited, usually consulted, and praised by way of researchers and reviewers alike. Now with greater than three hundred volumes (all of them nonetheless in print), the sequence includes a lot fabric nonetheless correct today--truly an important book for researchers in all fields of existence sciences
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Additional info for Sphingolipid Metabolism and Cell Signaling Part A
36, 1983 (1972). ~8H. U. Humpf, E. M. Schmelz, F. I. Meredith, H. Vesper, T. R. Vales, E. Wang, D. S. Menaldino, D. C. Liotta, and A. H. , J. BioL Chem. 273, 19060 (1998). 19B. M. Buehrer and R. M. Bell, Adv. Lipid Res. 26, 59 (1993). 20 SPHINGOLIPIDMETABOLISM [31 active site(s) of the microsomal ceramide synthase is localized to the cytosolic aspect of the endoplasmic reticulum, which is the same as for the earlier e n z y m e s of this p a t h w a y as well as with the side where fatty acylC o A is acquired.
Hannun, J. Biol. Chem. 272, 32566 (1997). 24 K. Krisnangkura and C. C. Sweeley, J. Biol. Chem. 251, 1597 (1976). 25 S. M. Mandala, R. A. Thornton, B. R. Frommer, S. Dreikorn, and M. B. Kurtz, J. Antibiot. 50, 339 (1997). 8 SPHINGOLIPIDMETABOLISM [ 1] cultures of suspended cells 8,26 and for assay of colonies of cultured cells. 27 Alternative ways of detecting the reaction p r o d u c t 3-ketosphinganine is include thin-layer c h r o m a t o g r a p h y and trapping of 14CO2 liberated f r o m [1-14C]serine or uniformly labeled [14C]serine.
H. Futerman, B. Stieger, A. L. Hubbart, and R. E. Pagano, J. BioL Chem. 265, 8650 (1990).  BIOSYNTHESIS OF SPHINGOMYELIN [51 A s s a y s f o r t h e B i o s y n t h e s i s o f S p h i n g o m y e l i n Ceramide Phosphoethanolamine 31 and B y MARIANA NIKOLOVA-KARAKASHIAN Introduction Sphingomyelin (N-acyl sphingosine phosphorylcholine, SM) is the primary sphingophospholipid in mammalian cells. As much as two-thirds of the total cellular sphingomyelin resides at the plasma membrane, where it plays important structural and functional roles.