By Brian E. Huber, Ian Magrath
The medical purposes of human gene remedy were relatively fruitful in oncology, and long ago twenty years there was explosive development in figuring out of the genetic lesions resulting in neoplasia. This quantity within the sequence melanoma: scientific technological know-how in perform stories growth within the simple and scientific technology of gene remedy in oncology, and appears towards destiny advancements. It considers what has labored and what has now not within the fast-evolving box of gene remedy, drawing on laboratory experiences and scientific trials, together with the ground-breaking paintings of the individuals themselves. modern and authoritative, the volumes during this sequence are meant for a large viewers of clinicians and researchers with an curiosity within the purposes of biomedical technological know-how to the certainty and administration of melanoma.
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Extra info for Gene Therapy in the Treatment of Cancer: Progress and Prospects (Cancer: Clinical Science in Practice)
Avilion, A. , Adams, R. , Allsopp, R. , West, M. , Harley, C. , Andrews, W. , Greider, C. W. and Villeponteau, B. (1995). The RNA component of human telomerase. Science, 269: 1236-70. Fishel, R. and Kolodner, R. D. (1995). Identification of mismatch repair genes and their role in the development of cancer. Current Opinion in Genetics and Development, 5: 382-95. Folkman, J. (1995a). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine, 1: 27—31. Folkman, J. (1995b). Angiogenesis inhibitors generated by tumors.
Science, 271: 1854—7. , Skorska, M. , Barletta, C. et al. (1993). Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisene oligodeoxynucleotides combined with mafosfamide. Journal of Clinical Investigation, 92: 194—202. Smetsers, T. , Van de Locht, L. T. et al. (1994). Antisense BCR-ARL oligonucleotides induce apoptosis in the Philadelphia chromosome-positive cell line 13V173. Leukemia, 8: 129-40. Stein, C. A. (1992). Anti-sense oligodeoxynucleotides - promises and pitfalls.
1992; Yang, Cedergren and Nada-Ginard, 1994; Cai, Mukhopadhyay and Roth, 1995). At the present time, the inhibition of a gene in vivo by the formation of a triplex molecule is extremely difficult to accomplish for a variety of technical reasons (see Transformation-directed cancer therapy 27 Fig. 8. Levels at which specificity could be introduced in a vectored system of gene targeting. Firstly, the vector itself (liposome or virus) could be rendered specific for a receptor expressed only on a limited fraction of cells.