By Freek Verheugt
This booklet is a realistic guide within the medical software of fibrinolytic remedy in a number of life-threatening issues. it isn't an encyclopedia for all trials in typically evidence-based treatment plans. it's intended for physicians caring for acute ailing sufferers both at in depth care devices, coronary care devices or emergency departments.
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Additional info for Fibrinolytic Therapy in Clinical Practice
Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 1994; 343:311–22. Franzosi MG, Santoro E, De Vita C et al. Ten year follow up of the first megatrial testing thromboloytic therapy in patients with acute myocardial infarction. Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’lnfarcto-1 Study.
Tenecteplase, in addition, has some resistance to tissue plasminogen activator inhibitors. Both reteplase and lanoteplase lack the finger domain of the parent molecule and thus have lower affinities for fibrin than alteplase, whereas tenecteplase has more. Antigenicity has not been a problem with any of these new molecules. The possibility of bolus administration of a thrombolytic drug increases the possibility of more rapid treatment after patient assessment in the receiving room, and the real opportunities for very early treatment in the community where most heart attacks occur.
Danish Multicenter Randomised Study of Invasive Versus Conservative Treatment in Patients with Inducible Ischemia After Thrombolysis in Acute Myocardial Infarction (DANAMI). Circulation 1997; 96:748–55. Thiemann DR, Coresh J, Schulman P et al. Lack of benefit of intravenous thrombolysis in patients with myocardial infarction who are older than 75 years. Circulation 2000; 101:2239–46. Boersma E, Maas AC, Deckers JW, Simoons ML. Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour.