By Federico Caligaris-Cappio, Riccardo Dalla Favera
Chronic lymphocytic leukaemia (CLL) is the commonest leukaemia within the Western global. it's also the prototype of B-cell power lymphoid malignancies and in their ramifications in the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now develop into the focal point of significant curiosity and progressively more investigators from various components, together with genetics, molecular biology, uncomplicated and utilized immunology have gotten actively engaged within the research of CLL. Clinicians are contemplating CLL as a really attention-grabbing aim of many initiatives which target at translating the recent and fascinating advancements of uncomplicated technology into potent new techniques to the sufferer.
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Extra resources for Chronic Lymphocytic Leukemia
32 2 B-CLL Shows a Homogeneous Gene Expression Proﬁle . . . . . . . 33 3 B-CLL Subtypes . . . . . . . . . . . . . . . . . . . . . 35 4 Cellular Derivation of B-CLL . . . . . . . . . . . . . . . . 37 5 B-CLL Pathogenesis . . . . . . . . . . . . . . . . . . . 41 6 Summary and Conclusions . . . . . . . . . . . . . . . . . 43 References . . . . . . . . . . . . . . . . . . . . . . . . . 44 Abstract For many decades, B cell chronic lymphocytic leukemia (B-CLL) stood out as a B cell-derived malignancy that was difﬁcult to position within the framework of the available B cell differentiation scheme: First, the histology as well as the immunophenotype did not quite resemble that of any normal lymphocyte; second, in contrast to almost all other B cell tumor subtypes, the immunoglobulin variable region (IgV) genes of B-CLL cases could be either unmutated or somatically mutated; third, the genomic lesions observed in B-CLL were markedly distinct from those of the other major B cell malignancies, which typically exhibit balanced chromosome translocations.
Dalla-Favera Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR (2002) Diffuse large Bcell lymphoma outcome prediction by gene-expression proﬁling and supervised machine learning. Nat Med 8:68–74 Stratowa C, Löfﬂer G, Lichter P, Stilgenbauer S, Haberl P, Schweifer N, Döhner H, Wilgenbus KK (2001) CDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafﬁcking.
2 B-CLL Shows a Homogeneous Gene Expression Profile Gene expression proﬁling using various gene chip “platforms” were performed by several laboratories during the last several years (Klein et al. 2001; Rosenwald et al. 2001; Stratowa et al. 2001; Dürig et al. 2003; Jelinek et al. 2003; Wang et al. 2004). The surprising theme that surfaced in these analyses was that all B-CLL cases displayed a common gene expression proﬁle that 34 U. Klein · R. Dalla-Favera is independent of the level of IgV gene somatic hypermutation (Klein et al.