By Ronald Breslow
This primary publication in this attention-grabbing subject is edited through one in every of latest most famed and across the world revered natural chemists, popular for his pioneering synthesis of the cyclopropenyl cation.
For his half, Ronald Breslow has introduced jointly best scientists during this increasing zone to supply a unique review of protein-, cyclodextrin-, steel- and porphyrin-based synthetic enzymes in addition to enzyme-like polymers and dendrimers.
A needs to for all scientists drawn to this rising field.
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Extra info for Artificial Enzymes
Sci. USA, 1996, 93, 10018–10021. 138 R. Breslow, A. Graff, J. Am. Chem. Soc. 1993, 115, 10988–10989. 139 J. M. Desper, R. Breslow, J. Am. Chem. Soc. 1994, 116, 12081–12082. 140 R. Breslow, J. Desper, Y. Huang, Tetrahedron Lett. 1996, 37, 2541–2544. -Q. Yuan, S. D. Dong, R. Breslow, Tetra- hedron Lett. 1998, 39, 7673–7676. 142 R. Breslow, P. Campbell, J. Am. Chem. Soc. 1969, 91, 3085. 143 R. Breslow, P. Campbell, Bioorg. Chem. 1971, 1, 140–156. 144 R. Breslow, H. Kohn, B. Siegel, Tetrahedron Lett.
0. 0, the optimum for pyridoxamine itself, it was 1900. We also found that transamination by simple pyridoxamine showed strong metal ion catalysis – adding 1 equiv. 5 Structure of the PEI-pyridoxamine systems. (Reprinted from Ref. 36. ) free pyridoxamine rate constant by 6000 times. However, the rate for the polymer increased by only 30-fold. The transaminase enzymes do not use metal ions.
Breslow, A. Adams, M. Brandl, T. Guo, J. Hunger, Lectures Heterocycl. Chem. 1987, IX, 43–49. R. Breslow, D. Heyer, Tetrahedron Lett. 1983, 24, 5039–5042. R. Batra, R. Breslow, Heterocycles 1989, 28, 23–28. D. Wiedenfeld, R. Breslow, J. Am. Chem. Soc. 1991, 113, 8977–8978. P. White, R. Breslow, J. Am. Chem. Soc. 1990, 112, 6842–6847. R. Breslow, A. Feiring, F. Herman, J. Am. Chem. Soc. 1974, 96, 5937–5939. R. Breslow, F. Herman, A. W. Schwabacher, J. Am. Chem. Soc. 1984, 106, 5359. R. Breslow, S.