By Ivor Benjamin MD FACC FAHA, Robert C. Griggs MD FACP FAAN, Edward J Wing MD FACP FIDSA, J. Gregory Fitz MD, Thomas E. Andreoli MD MACP FRCP(Edin)
Scholars, citizens, and teachers swear through Andreoli and Carpenter's Cecil necessities of drugs since it offers simply the correct quantity of knowledge, simply the fitting manner. Edited by means of the overdue Thomas E. Andreoli, MD in addition to Ivor Benjamin, MD, Robert C. Griggs, MD, and Edward J. Wing, MD, it makes a speciality of middle ideas and the way they follow to sufferer care, protecting every thing you want to recognize to be successful on a scientific rotation or residency. Masterful modifying and a hassle-free full-color layout make soaking up and maintaining details as easy as attainable, and pupil seek advice on-line entry bargains handy, versatile connection with the total contents of the booklet plus extra scientific images and radiologic photos, movies demonstrating systems, audio recordings of center and lung sounds, and extra. New chapters on "Pre- and Post-Operative Care" and "Palliative Care," plus the combination of molecular biology and different new horizons in medication, familiarize you with the most up-tp-date scientific strategies. scholar seek advice on-line entry bargains handy, versatile connection with the whole contents of the publication plus extra scientific pictures and radiologic pictures, movies demonstrating techniques, audio recordings of center and lung sounds, and extra. An increased foreign Editorial Board presents elevated enter from revered practitioners all over the world. first-class pictures and scientific images vividly illustrate the looks and medical positive aspects of ailment. Masterful enhancing and a ordinary full-color layout make soaking up and keeping info as easy as attainable. net icons through the revealed e-book name your recognition to extra content material to be had on-line thorough pupil seek advice. Your buy entitles you to entry the website until eventually the following variation is released, or till the present version is not any longer provided on the market by way of Elsevier, whichever happens first. Elsevier reserves the appropriate to supply an appropriate substitute product (such as a downloadable or CD-ROM-based digital model) may still on-line entry to the website be discontinued.
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Additional resources for Andreoli and Carpenter's Cecil Essentials of Medicine, 8th Edition (Cecil Medicine)
The cis-acting regulatory sequences to which transcription factors bind are often referred to as response elements. Families of transcription factors have been identified and are often described by unique aspects of their predicted protein secondary structure, including helix-turnhelix motifs, zinc-finger motifs, and leucine-zipper motifs. Transcription factors make up an estimated 3% to 5% of the protein-coding products of the genome. , beyond the 3′ end of the gene), and without clear orientation requirements.
Interestingly, some of these disorders evolved to protect the host. For example, sickle cell anemia evolved as protection against falciparum malaria, and cystic fibrosis developed as protection against cholera. Examples of polygenic disorders or complex disease traits include type 1 (insulin-dependent) diabetes mellitus, atherosclerotic cardiovascular disease, and essential hypertension. A common Table 1-2 Molecular Basis of Mutations Type Monogenic Disorders Autosomal dominant Autosomal recessive X-linked One of multiple mutations Examples Polycystic kidney disease 1, neurofibromatosis 1 β-Thalassemia, Gaucher disease Hemophilia A, Emery-Dreifuss muscular dystrophy Familial hypercholesterolemia, cystic fibrosis Polygenic Disorders Complex disease traits Type 1 (insulin-dependent) diabetes, essential hypertension, atherosclerotic disease, cancer 12 Section I—Introduction to Molecular Medicine example of a chromosomal disorder is the presence of an extra chromosome 21 (trisomy 21).
For functional analysis on a genome-wide scale, major technologic advances were made, including as high-throughput oligonucleotide synthesis, normalized and subtracted complementary DNA (cDNA) libraries, and DNA micro-arrays. In 1998, the Celera private venture proposed a similar goal as the Human Genome Project using a revolutionary approach, termed shotgun sequencing, to determine the sequence of the human genome (Web Movie 1-1). The shotgun sequencing method was designed for random large-scale sequencing and subsequent alignment of sequenced segments using computational and mathematic modeling.